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I-6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-enye Umfanekiso ofakiweyo
  • I-6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-enye
  • I-6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-enye

I-6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-enye

Inkcazelo emfutshane:

Igama leMchiza: 6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-enye

I-CAS: 1256578-99-0

Ifomula yemichiza:C13H15Bhuti2

Ubunzima bemolekyuli: 283.16

Ubuninzi: 1.3±0.1g/cm3

Iqondo lokubila:354.7±42.0 ℃(760 mmHg)

 


Iinkcukacha zeMveliso

Iithegi zeMveliso

Ingcaciso yeMveliso

Ubume bekhemikhali

I-6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-enye lulwelo olungenambala ukuya kumthubi olucacileyo, olunganyibilikiyo emanzini, olunyibilikayo kwi-CHCl3, ukugcinwa kufuneka kukhenkcezwe, kuhlulwe kwii-oxidants, iikhemikhali ezidliwayo, kude nomlilo, umthombo wokushisa.

Usetyenziso

I-6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-enyei-intermediate ye-Alectinib, i-inhibitor ye-anaplastic lymphoma kinase (ALK) ekhethiweyo kakhulu kwaye enamandla kakhulu ekwazi ukuvimba umgcini wesango ochasayo, obangela ukunciphisa ukukhula kweeseli.

Ubume bomzimba

Ulwelo olungenambala ukuya kumthubi

Beka ubomi kwishelufa

Ngokwamava ethu, imveliso ingagcinwa kwi-12Iinyanga ukusuka kumhla wokuhanjiswa ukuba zigcinwe kwizikhongozeli ezivaliweyo, zikhuselwe ekukhanyeni nakubushushu kwaye zigcinwe kumaqondo obushushu aphakathi kwe-5 -30°C.

Tiipropathi ezingokomfanekiso

Indawo yokubilisa

354.7±42.0 °C kwi-760 mmHg

Indawo yokuflasha

168.3±27.9 °C

IMisa ngqo

282.025543

PSA

26.30000

LogP

3.25

Uxinzelelo lomphunga

0.0±0.8 mmHg ku-25°C

Isalathiso seRefraction

1.545

pka

1.26±0.10(Kuqikelelwe)

Ukunyibilika kwamanzi

I-50 mg / ml kwi-CHCl3

 

 

Ukhuseleko

Xa uphethe le mveliso, nceda uthobele iingcebiso kunye nolwazi olunikwe kwiphepha ledatha yokhuseleko kwaye uqaphele amanyathelo okukhusela kunye nococeko lwasemsebenzini olwaneleyo lokuphatha imichiza.

 

Phawula

Iinkcukacha ezikule mpapasho zisekelwe kulwazi namava esinawo ngoku.Ngokujonga izinto ezininzi ezinokuchaphazela ukusetyenzwa kunye nokusetyenziswa kwemveliso yethu, ezi datha azibakhululi abaprosesa ekubeni benze olwabo uphando kunye novavanyo;kananjalo ezi datha azithethi nasiphi na isiqinisekiso sezinto ezithile, okanye ukufaneleka kwemveliso ngeenjongo ezithile.Naziphi na iinkcazo, imizobo, iifoto, idatha, imilinganiselo, iintsimbi, njl.njl ezinikwe apha zingatshintsha ngaphandle kolwazi lwangaphambili kwaye azenzi umgangatho wekhontrakthi ekuvunyelwene ngayo kwimveliso.Umgangatho wekontraka ekuvunyelwene ngawo wemveliso uphuma kuphela kwiingxelo ezenziwe kwingcaciso yemveliso.Kuluxanduva lomamkeli wemveliso yethu ukuqinisekisa ukuba nawaphi na amalungelo obunini kunye nemithetho ekhoyo kunye nomthetho uyaqwalaselwa.

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