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Umfanekiso obonisiweyo we-6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one
  • I-6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one
  • I-6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one

I-6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one

Inkcazo emfutshane:

Igama lekhemikhali: 6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one

I-CAS: 1256578-99-0

Ifomula yekhemikhali: C13H15UBrO2

Ubunzima beMolekyuli: 283.16

Uxinano：1.3±0.1g/cm3

Iqondo lokubila：354.7±42.0 ℃（760 mmHg）

 


Iinkcukacha zeMveliso

Iithegi zeMveliso

Ingcaciso yeMveliso

Iikhemikhali

I-6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one lulwelo olucacileyo olungenambala ukuya koluphuzi olukhanyayo, olunganyibilikiyo emanzini, olunyibilikayo kwi-CHCl3, indawo yokugcina kufuneka iqandiswe, yahlulwe kwii-oxidants, iikhemikhali ezityiwayo, kude nomlilo, kunye nomthombo wobushushu.

Izicelo

I-6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-onesisixhobo esiphakathi se-Alectinib, i-anaplastic lymphoma kinase (ALK) inhibitor ekhetha kakhulu nenamandla ekwaziyo ukuthintela i-gatekeeper mutant enganyangekiyo, nto leyo ekhokelela ekukhuleni okunciphileyo kweeseli.

Imo ebonakalayo

Ulwelo olungenambala ukuya kolutyheli

Beka ubomi kwishelufa

Ngokweengxelo zethu, imveliso ingagcinwa kangangeentsuku ezili-12.iinyanga ukususela kumhla wokuhanjiswa ukuba zigcinwe kwizikhongozeli ezivalwe kakuhle, zikhuselwe ekukhanyeni nakubushushu kwaye zigcinwe kumaqondo obushushu aphakathi kwe-5 -30°C.

Tiipropati eziqhelekileyo

Indawo yokubilisa

354.7±42.0 °C kwi-760 mmHg

Indawo yokuflasha

168.3±27.9 °C

Ubunzima obuchanekileyo

282.025543

I-PSA

26.30000

I-LogP

3.25

Uxinzelelo lomphunga

0.0±0.8 mmHg kwi-25°C

Isalathiso seRefraction

1.545

i-pka

1.26±0.10(Kuqikelelwe)

Ukunyibilika Kwamanzi

50 mg/ml kwi-CHCl3

 

 

ukhuseleko

Xa uphatha le mveliso, nceda ulandele iingcebiso nolwazi olunikiweyo kwiphepha ledatha yokhuseleko kwaye ulandele amanyathelo okhuseleko kunye nococeko kwindawo yokusebenza afanelekileyo okuphatha iikhemikhali.

 

Phawula

Idatha equlethwe kule ncwadi isekelwe kulwazi lwethu lwangoku namava. Ngenxa yezinto ezininzi ezinokuchaphazela ukucutshungulwa nokusetyenziswa kwemveliso yethu, le datha ayibakhululi abaprosesa ekwenzeni uphando lwabo kunye novavanyo; kwaye le datha ayithethi siqinisekiso seempawu ezithile, okanye ukufaneleka kwemveliso ngenjongo ethile. Naziphi na iinkcazo, imizobo, iifoto, idatha, ubungakanani, ubunzima, njl.njl. ezinikwe apha zinokutshintsha ngaphandle kolwazi lwangaphambili kwaye aziyiyo umgangatho wesivumelwano esivunyiweyo wemveliso. Umgangatho wesivumelwano esivunyiweyo wemveliso uvela kuphela kwiingxelo ezenziwe kwinkcazo yemveliso. Luxanduva lomntu ofumana imveliso yethu ukuqinisekisa ukuba nawaphi na amalungelo obunini kunye nemithetho ekhoyo kunye nomthetho ziyalandelwa.

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